PO-02-183 ATRIO-VENTRICULAR DISSOCIATION IN PREMATURE VENTRICULAR CONTRACTION WITH DIFFERENT COUPLING INTERVALS

The pathophysiology of Premature ventricular contraction (PVC) induced cardiomyopathy (PVC-CM) remains unclear. AV dissociation (AVD) during PVCs is known as atrial at the time PVC. AVD has been implicated a potential trigger and predictor PVC-CM, especially early since it results in an increase LA pressure due to mitral valve closure. goal this study was assess short- long-coupled PVCs, its correlation with development PVC-CM. Thirty-one canines underwent implantation 1) modified pacemaker reproduce RV apical 2) telemetry device bipole implanted appendage record local electrograms PVCs. Animals were randomized short-coupled (200ms, n=14), (330ms, n=8) bigeminal or no (sham, n=11). categorized absent (no P wave QT interval), (P present between QRS peak T PVC), late end PVC). for four 1-minute segments (6 AM, 12 PM, 6 AM) 24 hours LV ejection fraction assessed after weeks 1, 4, Ponemah software used HR analysis calculate minimum, maximum, average PVC burden. Overall similar throughout (Panel A). Short-coupled had 35% 21% AVD, respectively 44%. Long-coupled 50% 13% respectively, without 37% B). significantly higher compared (50% vs. 35%, Two-Way ANOVA P<0.001), while (22% 13%, ANOVA, p=0.018) A &C). Neither short nor showed significant reduction LVEF (r=0.09, r=0.06 p=0.5, p=0.8, respectively). increased relative sham groups (121 105 83, p<0.001). Moreover, than 105, p< 0.001). Early more pronounced does not predict PVC-CM regardless coupling interval, suggesting that play role